Mitochondrial metabolism drives inflammatory ageing via epigenetic crosstalk

In senescent cells, mitochondria-derived acetyl-CoA promotes histone acetylation and increases chromatin accessibility at inflammatory gene sites, fuelling the senescence-associated secretory phenotype (SASP). Inhibiting the transporter SLC25A1 reduces these effects. The findings identify mitochondrial metabolism as a potential therapeutic target for slowing age-related functional decline.

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🏥 Health Fertility clinics offer young mitochondria injections despite lack of safety data Nature · 2d ago 🏥 Health Mediterranean diet boosts heart- and brain-protecting mitochondrial proteins Science Daily · 12d ago 🔬 Science Scientist Martin Picard tests his mitochondrial theory of mind on himself Quanta Magazine · 13d ago

More on this topic

🏥 Health Fertility clinics offer young mitochondria injections despite lack of safety data Nature · 2d ago 🏥 Health Mediterranean diet boosts heart- and brain-protecting mitochondrial proteins Science Daily · 12d ago 🔬 Science Scientist Martin Picard tests his mitochondrial theory of mind on himself Quanta Magazine · 13d ago