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Decades-old compound TOFA burns fat without muscle loss — boosts GLP-1 drugs too
A decades-old compound called TOFA may offer a new approach to obesity treatment by boosting the body's energy use rather than suppressing appetite. In mice, it increased energy expenditure by up to 18%, reduced body fat without significant muscle loss, and improved blood sugar, triglycerides and fatty liver disease. Combined with GLP-1 drugs such as Ozempic, Wegovy and Mounjaro, results were even stronger.
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