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Brain circuit controlling morphine reward learning identified in new study
A study published in Nature found that blocking opioid receptors specifically in cholinergic interneurons of the nucleus accumbens eliminates morphine reward learning without affecting pain relief. The mechanism involves decoupling morphine-induced dopamine rises from acetylcholine dips in this brain region. Researchers suggest that pro-cholinergic strategies could help limit early opioid addiction without removing analgesic benefits.
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