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Cryo-EM Reveals How Trypanosomes Edit Their Mitochondrial RNA

Cryo-electron microscopy has revealed the detailed architecture of the mitochondrial editosome in Trypanosoma brucei, the parasite responsible for African sleeping sickness. The study explains how the complex mediates mRNA editing through precise insertion and deletion of uridine nucleotides. The findings could point to new drug targets against trypanosomal diseases.