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Alzheimer's study restores two hours of sleep by removing overactive brain immune cells
Researchers have identified overactive microglia — the brain's immune cells — as a key cause of sleep loss in mice with Alzheimer's disease. These cells trigger inflammation that prevents deep, restorative sleep; temporarily removing most of them restored over two hours of sleep per day even though amyloid plaques remained intact. The findings suggest new therapeutic approaches for Alzheimer's-related sleep disruption that do not rely on clearing brain plaques.
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